Bitten by a radioactive spider, nerdy Peter Parker was gifted with the proportionate strength and agility of a spider. Seeing an opportunity to make money from his new abilities, his selfish actions indirectly led to the death of his Uncle Ben. Seeking to atone for his mistakes, Peter vowed to always use his abilities selflessly, no matter the cost.. and it has cost him dearly.
Spider-Man has a lost many of those closest to him (Captain George Stacy, Gwen Stacy, Jean DeWolff), had his life mercilessly toyed with (Clone Saga, Superior Spider-Man), and sacrificed one love for another (One More Day). Although historically a loner, he has been a mighty Avenger and a member of super-science team, the Fantastic Four. And while he has been known to give up the long-underwear (Spider-Man No More!), he has shown time and again that no threat is too great (Maximum Carnage, Spider-Island) for the amazing, the spectacular Spider-Man.
Kraven the Hunter